Vetoquinol Zylkene Calming Support Supplement for Small Dogs and Cats, Promotes Relaxation, Reduces Stress, and Supports Occasional Anxiety Relief for Dogs and Cats, 75mg - 14 Capsules

My kitty Goose is the only one of 4 indoor cats we have that has had a terrible problem of marking (he’s 10 this year and this began 2 years ago) in one room of the house. Same spot over and over, no amount of enzyme cleaner or cleaning of the area and direct spot cleaning has made him stop. I was at my wits end and didn’t know what other steps to take, before going to the vet (he has been cleared of any medical complications) for prescribed medication, I figured I’d give this a shot. I give him one pill in the morning mixed with a quarter of his squeezable treat and he has completely stopped, he is much calmer overall, and actually seems at peace now. There are no side affects aside from the first dose where he literally looked like he was stoned for about an hour lmfao that has since stopped, and he acts completely normal after his dose (for his weight is recommended two, I only give him one) and he doesn’t notice any taste or smell from it, he gets excited when I shake the bottle in the mornings to mix it for him! I highly recommend this product for people struggling with a cat who has high anxiety or marking issues! From a very relieved cat mom who was ready to throw in the towel.

Great product just a little expensive

I find this good for calming. It’s hard to say if this alone is helping but I do see a difference. It helps if it’s taken daily rather than as needed. It’s expensive so taking off one star.

It took a week or so but my 17 yea old cat with dementia and other illnesses calmed down. He had been up all night, yowling and walking up and down our bed multiple times. Now he seems much more comfortable and able to relax at night. It’s not 100% but way better than before. I have to put it in a pill popper to give it to him but you could open the capsule and sprinkle on food.

I have a small terrier with allergies and anxiety. For her to be happy, I have to manage both. This product does a good job of relaxing her, though it is not the only thing I use. I do notice when I stop using it she is antsier, so I have chosen to continue the product. But the price continues to increase from expensive to untenable. I looked around for alternatives. The active ingredient is called Alpha-Casozepine, according to the label. So, in looking for products with this, it turns out that Lactium is a trademarked version of this. It was difficult to find a product with this alone. Ultimately, I found a Swanson Antistress human product that contained only this as an active ingredient. There are other products that have this ingredient along with other things that I didn't want. I'll see how this new product works once I receive it. Interestingly, Calmkeen, a product that markets itself as similar, has hydrolyzed milk protein as the active ingredient, but it does does not have the actual Alpha-Casozepine. I bought it to alternate with Zylkene, but it simply does not work as well for my dog. And the price, which is significantly cheaper than Zylkene, has continued to rise likely because Zylkene's has. Anyway, if money is no option, then Zylkene is an effective product. If you don't want to continue to pay chronic price increases, you may need to look for an alternative.

Update 2 months: This is absolutely necessary to keep the peace in my household. I have started to give her slightly more than 75mg, because it wasn’t working as well after a while but giving her 1 pill plus a little sprinkle from the second pill works great. She is just over the weight suggested for the 75mg. I tried to give it every other day but it just was not working as well as every day. We still smoosh it into a few pill pockets and make like a dough and then I pinch off treat size pieces and she loves it! She cries for it every morning and that is what she wants for breakfast lol. She’s now refusing wet food because this is what she wants. Update 7 days after initial review: I have been giving 1/2 of a 75mg capsule twice a day to my cat for 7 days straight now and she has not attacked my other cat in 7 days! We usually have stalking and attacking constantly so to go from constantly to none is very impressive! What I really like is that she still has her personality and does not seem drugged in any way. She just isn’t a psychopath stalker anymore 🤷🏻‍♀️. I plan on continuing the regimen and giving 1/2 to her twice a day. I started by sprinkling half a capsule on her wet food but she doesn’t eat all of it (she doesn’t mind the powder at all) so instead I have been buying pill pockets and I just knead it into the pill pocket like a dough and she eats it right up. This way she gets the full dose and I’m not wasting any. Initial review: My vet recommended that I try this before we put my cat on Prozac. I have two cats. My cats are not litter mates, they are both 6 years old and I adopted them one year apart. Pandora was the second cat I adopted and she has turned out to be a little psychopath. She constantly bullies and stalks and chases and attacks my other cat. It drives me insane and at times it’s extremely draining. I have tried very good quality lab tested CBD, and every kind of feliway spray and diffuser there is. Nothing works. I purchased this about 8 months ago and the first time I gave it to her she full on attacked my foot (not playing, it was very aggressive) and she has never done that before. So I have not given it to her again. Out of desperation, I am revisiting this option, after reading more about how to administer, I think she probably just needs more time to adjust. I sprinkled half of one capsule on top of about a tablespoon of wet food. She ate almost all of it right away. I purchased some pill pockets and I think I can smush the powder into them and feed it to her that way to ensure she gets as much of the product as possible without wasting any. She goes crazy for pill pockets! I’ll gladly update this review once we finish the bottle. Tonight was the first night we started it again and she walked around the house looking for something to get into for about 30 minutes (typical) and then laid down and went to sleep.

Heard of this supplement from a breeder at a cat show. She suggested it for my 8 month old overly rambunctious Tonkinese kitten. After a month he has settled down considerably and has learned some boundaries. This seems to have no taste or smell. I mix it with a treat or his wet food and he doesn’t seem to notice it. I will continue to use it while maturity on his part with his teenage angst and emotions even out.

I have a 4-year-old Maine Coon with a sensory processing disorder. My big boy, Barnum, has trouble processing textures and noises. I have the only Maine Coon in America who HATES to be brushed no matter the brush or comb used. (We have 12.) Everyday noises — the doorbell, microwave alarm, TV volume — completely unhinge him and send him running for his life. Prozac helped to some degree, but it also flattened him emotionally and didn’t fully address the sensory overload. Since adding Zylkene alongside an reduced Prozac dose, the change has been remarkable. Barnum is calmer (no longer flinching when the duct work in the attic pops or the ice maker drops ice), more social, and genuinely enjoying life again. He seeks affection, engages in play, and even participates in brush sessions willingly (with freeze dried chicken incentives!). The difference is subtle but profound — his nervous system feels soothed, not sedated. I give him 1 capsule every morning. 2 made him sleep all day. Zylkene has balanced his sensory overload and allowed his personality and spirit to come back. He’s alert but regulated, playful but not anxious, and much more comfortable navigating the household and daily life. Any owner of a cat with anxiety or sensory issue should try Zylkene. Worth every penny!

All in good condition.