HPN NAD3 Clinical NAD+ Booster, Cellular Health & Natural Energy - NAD Supplement for Healthy Aging, Metabolic Support, NRF2 & Longevity, Nicotinamide Riboside & NMN Alternative, 60ct, 30-Day Supply

I am a 65 year old female who has had cancer twice, and have been in remission from stage 4 metastatic cancer for 11 years, due in part I believe to a regimen of supplements including resveratrol, quercetin, Vitamin C, Vitamin D3, and many others. I also walk 3 miles per day, and have tried to avoid sugar and refined carbs for much of that time. Throughout the years I have been following anti-aging and anti-cancer research, as a curious layperson. I have explored writings and videos by David Sinclair of Harvard, Leonard Guarente of MIT, and others, leading me to the recent reports on the postulated benefits to humans of NAD precursor, Nicotinimide Riboside. Leonard Guarente himself takes it, according to his Elyseum website. I started taking the recommended dose in early February, 2015, and can report some positive results, although I believe the dosage level is critical and probably varies widely, depending on one’s age and health status. My experience has been that the prescribed dose of 250 mg. is simply too much. It revved me up, but the rebound effect was very noticeable--exhaustion. A suitable analogy might be constantly gunning and red-lining one’s old, inefficient engine. So I cut back to a half dose every other day. Much better. I still feel energetic--and optimistic--but am not completely exhausted hours later after the initial burst of energy has waned. It would certainly seem logical that younger, healthy, and/or athletic folks already have sufficient amounts of NAD, so they probably wouldn't notice much if any improvement from supplementation with NR. However, old folks have NAD deficiency as a result of aging, and probably see a much greater benefit from supplementation with NR. which increases NAD. I am guessing that most of the folks reporting little or no benefit from NR are either younger & healthy and have plenty of NAD; or, perhaps are taking far more than they need, producing some sort of negative hormesis-like response; or are not taking complementary doses of resveratrol, or other pterostilbenes, which operate in tandem with NAD as a substrate to influence anti-aging sirtuins. An update: I am now 68 and still taking NR from various makers, who add various components along with NR (all Niagen based) and at various dosages.. The 250 mg. dose is now my standard, however, and I no longer have the exhaustion effect. I don't know why, but it is gone and I am feeling great. I always take resveratrol daily, and many other supplements as noted above. I am also considering the other NAD precursor which is starting to become available, nicotinamide mononucleotide, but the price has got to come down significantly and some major advantage over NR demonstrated. Another possible effect from taking the 250 mg. NR dose is noteworthy: my fasting blood sugar is now running in the 60's and 70's regularly, but I do not feel bad. I have been doing a form of intermittent fasting for some time, but even when I have a regular meal, a few hours later my fasting glucose is back in the 60's & 70's. I test it daily. This may in fact serve as a long-term indicator of the continued efficacy of NR. I have never had fasting glucose levels this low, before taking 250 mg. of NR daily.

Its a great product! The 1st day you take it you notice you have more energy. However, the nature of our bodies is to get used to things, so after a few days you’ll not notice what you did at first. But, it is still working hard for you! And in a couple of weeks you will notice that you are thinking clearer, your thinking is more focused, and you have a better attitude towards things. A better attitude because the mind is now ‘more together’ and therefore more efficient! I like this for me. This supplement is not about feeling super energetic all the time, feeling like a superhero. Instead, its about providing you with results that when combined with a healthy lifestyle can help you get closer to reaching your highest potential. I recommend this product. Thank you HPN!

This is my main supplement for energy and mental clarity. I take this every day and I can feel a dramatic difference when I don’t take it. I have used many other NAD supplements and this is by far my favorite. Just solid energy and mental clarity. I trust this brand to other supplements as well.

EXCELLENT PRODUCT! packaged in GROSSLY EXCESSIVE PLASTIC — bottle is, at most, 1/4 full.

excelente

Im 64, i took one capsule before breakfast and soon after i couldnt stay awake and slept for almost 2 hrs and then just lay there unable be fully awake enough to get up for another hour, a few hours later i started to feel very brief pains not in but near joint areas randomly around my body. Dont know what to make of all this, so far nothing i can call positive has happened, ive only taken the one capsule i wont be taking a second one today, ill have to decided about taking one again tomorrow. I can only give it 3 stars at this point till I learn more. I do like the new bottle though, the way you twist the top and the clear part opens up with a hole to let the capsules out, its a unique design.

Excellent,

I had read articles about the human anti-aging trials starting this year so I took a chance on this. I'm 49 and I don't know about feeling 20 again, but I definitely feel like I'm 35 again. I started lifting weights again this past year (former college wrestler and coach) and had consigned myself to being to old to lift like I did even in my mid thirties. So I cut back on my workout routines, instead of doing 16 sets per muscle group, I had to cut back to 8 - 12 sets per muscle group. I figured at this age (going on 50) doing anything was good. Within 1 week of taking the Niagen I somehow had the energy to pump out 16 sets. I don't come home tired from work and only work out on weekends or have to slam caffeine pills and energy boosters to get a workout in. I feel good every day. I did my research and from what I gather this product works better for older people, the young body builders didn't report much of anything. But from my understanding this product helps protect the brain in contact sports, so I don't want to turn off everyone young. I have 3 sons that play football and if this product was cheaper I would put them on it.

I have only tried this and one other brand that was 333 mg. I like the one that is 300 mg. On the forums concerning niagen its really only recommended for 35 years plus and many don't notice differences until in their 50's, because their bodies are producing adquate sirts, ie sirt 1 3 6, etc. I'm 54 with arthritis, chronic fatigue and other issues and noticed immediate results in energy but also in arthritic pain and joint issues. And had moderate weight loss. Going to stick with this in the long run. Have my parents on this as well. Whether or not it induces longevity or whether it just gives quality of life, the B3's are very needed, and this is one of them. Niacin, Niacidamide and Niagen all use different pathways with the sirt activity. You can take all 3. However tend to get headaches on niacin. They all create the sirts or increase them.

I give this product 5 star

Didnt see nor feel any difference

المنتج ممتاز

I am 80+ years old, and suffer from loosing energy very easily during the day after getting up, and not getting enough sleep on daily basis. I have tried different types of supplements including NMN and other types of vitamin in nature until the time I found this NAD3 from Amazon. I felt the results after 2 weeks taking this supplements. At first My sleep gets better and better, faster and longer up to 6 - 7 hours compared to previously 2 - 3 hours. After getting up in the morning, I feel sharp in mind and get more interested in doing many things that I felt tired in doing in the previous time. Even better I feel more energetic during the whole day, doing different types of house works, like cooking, cleaning and washing. Thanks to NAD3 and I will recommend it to my friends.